Structure of PDB 5yc8 Chain A

Receptor sequence
>5yc8A (length=384) Species: 562,9606 [Search protein sequence]
SPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSL
ACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNARVMNLL
IISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFI
VGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKA
DLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDK
SPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAY
IQKYLSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTI
GYWLCYINSTINPACYALCNATFKKTFKHLLMCH
3D structure
PDB5yc8 Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3C0 A D103 Y104 S107 N108 W155 A191 A194 W400 Y403 N404 Y426 C429 D88 Y89 S92 N93 W140 A176 A179 W326 Y329 N330 Y352 C355 MOAD: Kd=6.4nM
PDBbind-CN: -logKd/Ki=8.19,Kd=6.4nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0016907 G protein-coupled acetylcholine receptor activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042597 periplasmic space

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5yc8, PDBe:5yc8, PDBj:5yc8
PDBsum5yc8
PubMed30420692
UniProtP08172|ACM2_HUMAN Muscarinic acetylcholine receptor M2 (Gene Name=CHRM2);
P0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC)

[Back to BioLiP]