Structure of PDB 5yb1 Chain A

Receptor sequence

>5yb1A (length=581) Species: 9606 (Homo sapiens) [Search protein sequence]

HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKT
CVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECF
LQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAP
ELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCAS
LQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLE
CADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADL
PSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKT
YETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYK
FQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDY
LSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEF
NAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFA
AFVEKCCKADDKETCFAEEGKKLVAASQAAL

3D structure

PDB

5yb1 Developing an Anticancer Copper(II) Multitarget Pro-Drug Based on the His146 Residue in the IB Subdomain of Modified Human Serum Albumin.

Chain

Resolution

2.616 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	PLM	A	R117 L135 Y138 L139 Y161	R115 L133 Y136 L137 Y159
BS02	PLM	A	V23 Y150 A254 R257 L283 S287	V21 Y148 A252 R255 L281 S285
BS03	PLM	A	S342 V344 R348 L453 R485	S340 V342 R346 L451 R483
BS04	PLM	A	Y411 V418 L457 L460 H464 S489	Y409 V416 L455 L458 H462 S487
BS05	PLM	A	Y401 F507 K525 A528 L529 M548 F551 S579	Y399 F505 K523 A526 L527 M546 F549 S577
BS06	PLM	A	A210 D324	A208 D322
BS07	PLM	A	K199 H242 R257 I264 I290	K197 H240 R255 I262 I288
BS08	8ZR	A	L115 I142 R145 H146 G189	L113 I140 R143 H144 G187

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0005504	fatty acid binding
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0015643	toxic substance binding
GO:0016209	antioxidant activity
GO:0019825	oxygen binding
GO:0030170	pyridoxal phosphate binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0051087	protein-folding chaperone binding
GO:0140272	exogenous protein binding
GO:1903981	enterobactin binding

	Biological Process
GO:0009267	cellular response to starvation
GO:0051902	negative regulation of mitochondrial depolarization
GO:0072732	cellular response to calcium ion starvation
GO:0098869	cellular oxidant detoxification

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0031093	platelet alpha granule lumen
GO:0032991	protein-containing complex
GO:0070062	extracellular exosome
GO:0072562	blood microparticle

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5yb1, PDBe:5yb1, PDBj:5yb1
PDBsum	5yb1
PubMed	29722993
UniProt	P02768\|ALBU_HUMAN Albumin (Gene Name=ALB)

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