Structure of PDB 5yak Chain A

Receptor sequence
>5yakA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
EHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVIR
TAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVT
DLKKLRTNWIKEYLDTAPILILIFKQVHGFAGKKKVHYYNEISVSIACGI
LLAALQNAGLVTVTTAPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEAT
VPDLKRKPLDQIMVT
3D structure
PDB5yak Redox control of iodotyrosine deiodinase
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.21.1.1: iodotyrosine deiodinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A R100 R101 S102 R104 L176 T237 T238 A239 R29 R30 S31 R33 L105 T164 T165 A166
BS02 YOF A E157 Y161 W169 L173 K182 E86 Y90 W98 L102 K111 MOAD: Kd=1.5uM
BS03 FMN A P127 S128 G129 H131 Y212 P56 S57 G58 H60 Y139
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:5yak, PDBe:5yak, PDBj:5yak
PDBsum5yak
PubMed30052294
UniProtQ6PHW0|IYD1_HUMAN Iodotyrosine deiodinase 1 (Gene Name=IYD)

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