Structure of PDB 5y8y Chain A

Receptor sequence
>5y8yA (length=133) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHHHLVPRGSNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWP
FQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTM
FTNCYIYNKPGDDIVLMAEALEKLFLQKINELP
3D structure
PDB5y8y Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
ChainA
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8PX A W81 L94 N140 I146 M149 W49 L62 N108 I114 M117 MOAD: Kd=82nM
PDBbind-CN: -logKd/Ki=7.09,Kd=82nM
External links
PDB RCSB:5y8y, PDBe:5y8y, PDBj:5y8y
PDBsum5y8y
PubMed29566488
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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