Structure of PDB 5y8m Chain A

Receptor sequence
>5y8mA (length=289) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFRSA
PEAVAEADVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDARE
VHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLEPM
AGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSLFD
VITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNKDLGLAMDA
VAATGATAPLGSHAADIYAKFAADHADLDFSAVIHTLRA
3D structure
PDB5y8m Structure, interactions and action ofMycobacterium tuberculosis3-hydroxyisobutyric acid dehydrogenase.
ChainA
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.31: 3-hydroxyisobutyrate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9ON A R145 E149 A152 R144 E148 A151
Gene Ontology
Molecular Function
GO:0008442 3-hydroxyisobutyrate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006574 valine catabolic process
GO:0009083 branched-chain amino acid catabolic process
GO:0016054 organic acid catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5y8m, PDBe:5y8m, PDBj:5y8m
PDBsum5y8m
PubMed29959185
UniProtP9WNY5|MMSB_MYCTU Probable 3-hydroxyisobutyrate dehydrogenase (Gene Name=mmsB)

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