Structure of PDB 5y7z Chain A

Receptor sequence
>5y7zA (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
SQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLS
NEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLT
ELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRD
LKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTT
PMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVN
GKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVN
PKSPITELLEQN
3D structure
PDB5y7z Structural Basis for the Inhibition of Cyclin G-Associated Kinase by Gefitinib.
ChainA
Resolution2.804 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D173 K175 N178 D191 T223
Catalytic site (residue number reindexed from 1) D150 K152 N155 D168 T200
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IRE A L46 K69 C126 K127 G128 E132 L180 C190 L23 K46 C103 K104 G105 E109 L157 C167 PDBbind-CN: -logKd/Ki=7.81,Kd=15.4nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5y7z, PDBe:5y7z, PDBj:5y7z
PDBsum5y7z
PubMed30214852
UniProtO14976|GAK_HUMAN Cyclin-G-associated kinase (Gene Name=GAK)

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