Structure of PDB 5y6z Chain A

Receptor sequence

>5y6zA (length=457) Species: 31704 (Coxsackievirus A16)

GEIQWMKSNKETGRLNINGPTRTKLEPSAFYDVFEGSKKPAVLTSKDPRL
EVDFEQALFSKYVGNTLHEPDEYVTQAALHYANQLKQLDINVNKMSMEEA
CYGTEYLEAIDLHTSAGYPYSALGVKKRDILDPITRDTTKMKFYMDKYGL
DLPYSTYVKDELRSLDKIRKGKSRLIEASSLNDSVYLRMTFGHLYETFHA
NPGTVTGSAVGCNPDVFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALE
VVLREIGYPEEAVSLIEGINHTHHVYRNRTYCVLGGMPSGCSGTSIFNSM
INNIIIRTLLIKTFKGIDLDELHMVAYGDDVLASYPFPIDCLELAKTGKE
YGLTMTPCFNEVTWENATFLKRGFLPDHQFPFLIHPTMPMREIHESIRWT
KDARNTQDHVRSLCLLAWHNGKEEYEKFVSTIRSVPIGRALAIPNYENLR
RNWLELF

3D structure

• PDB: 5y6z Crystal structure of the coxsackievirus A16 RNA-dependent RNA polymerase elongation complex reveals novel features in motif A dynamics
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.29: picornain 2A.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	P20 E108 T114 S115 K127 Y157 K159 I176 A178 R188 H199 G211 C212 N213 S289 G290 C291 Y327 D413 R416 L420	P20 E108 T114 S115 K127 Y157 K159 I176 A178 R188 H199 G211 C212 N213 S289 G290 C291 Y327 D408 R411 L415
BS02	rna	A	H113 S295 Y327 G328 L375 S401 N410 D413 H414 S417	H113 S295 Y327 G328 L370 S396 N405 D408 H409 S412

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:5y6z, PDBe:5y6z, PDBj:5y6z
• PDBsum: 5y6z
• PubMed: 29164396
• UniProt: L7WS61