Structure of PDB 5y5n Chain A

Receptor sequence
>5y5nA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
GEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLV
GAGISTSAGIPDFRSPHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFK
PTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSH
CVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFF
SCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAYRDV
AWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQS
3D structure
PDB5y5n Potent mechanism-based sirtuin-2-selective inhibition by anin situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P94 D95 F96 R97 N168 D170 H187
Catalytic site (residue number reindexed from 1) P61 D62 F63 R64 N124 D126 H143
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C195 C200 C221 C224 C151 C156 C177 C180
BS02 8NO A F96 R97 F119 F131 A135 P140 F143 I169 F190 I232 V233 F63 R64 F75 F87 A91 P96 F99 I125 F146 I188 V189 PDBbind-CN: -logKd/Ki=5.76,IC50=1.74uM
BindingDB: IC50=1000nM
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5y5n, PDBe:5y5n, PDBj:5y5n
PDBsum5y5n
PubMed28989670
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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