Structure of PDB 5y4z Chain A

Receptor sequence
>5y4zA (length=440) Species: 64320 (Zika virus) [Search protein sequence]
CFEPSMLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKKRLRTVILAPTRV
VAAEMEEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTSRLLQPIRVP
NYNLNIMDEAHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFP
DSNSPIMDTEVEVPERAWSSGFDWVTDHSGKTVWFVPSVRNGNEIAACLT
KAGKRVIQLSRKTFETEFQKTKNQEWDFVITTDISEMGANFKADRVIDSR
RCLKPVILDGERVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYMYGGGC
AETDEGHAHWLEARMLLDNIYLQDGLIASLYRPEADKVAAIEGEFKLRTE
QRKTFVELMKRGDLPVWLAYQVASAGITYTDRRWCFDGTTNNTIMEDSVP
AEVWTKYGEKRVLKPRWMDARVCSDHAALKSFKEFAAGKR
3D structure
PDB5y4z Structural view of the helicase reveals that Zika virus uses a conserved mechanism for unwinding RNA
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A P196 G197 G199 K200 T201 R202 E286 R462 P19 G20 G22 K23 T24 R25 E109 R285
BS02 MN A T201 E286 T24 E109
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5y4z, PDBe:5y4z, PDBj:5y4z
PDBsum5y4z
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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