Structure of PDB 5y4q Chain A

Receptor sequence
>5y4qA (length=273) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
GWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMAL
DGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHG
TVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPD
NTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRE
TGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDL
KYYDSEMHKASFALPRFARHINN
3D structure
PDB5y4q Discovering a hidden allosteric binding site by combining molecular simulations and X-ray crystallography
ChainA
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M A Q40 L59 Q64 G95 D98 D118 I119 V123 D149 G150 D168 T169 Q31 L50 Q55 G86 D89 D109 I110 V114 D140 G141 D159 T160
BS02 8OF A E14 M24 W53 I63 D69 Y73 T236 Y237 P238 E5 M15 W44 I54 D60 Y64 T215 Y216 P217
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5y4q, PDBe:5y4q, PDBj:5y4q
PDBsum5y4q
PubMed37521650
UniProtQ4DA73

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