Structure of PDB 5y4h Chain A

Receptor sequence
>5y4hA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLQDVAELIRARACQRVVVMVGAGISTPSGIPDQYDLPYPEAIFELPFF
FHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLER
VSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTG
VVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVR
SSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRD
LVQRETG
3D structure
PDB5y4h Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P155 D156 N229 D231 H248
Catalytic site (residue number reindexed from 1) P33 D34 N94 D96 H113
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide A F180 H248 V292 F294 E296 L322 E323 V324 E325 W353 F45 H113 V157 F159 E161 L187 E188 V189 E190 W218
BS02 ZN A C256 C259 C280 C283 C121 C124 C145 C148
BS03 8QF A Q300 R301 V307 Q165 R166 V172
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5y4h, PDBe:5y4h, PDBj:5y4h
PDBsum5y4h
PubMed29184120
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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