Structure of PDB 5y49 Chain A

Receptor sequence
>5y49A (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
LTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNH
VQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNPSGHSDL
LEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQY
IKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHH
AEMLMSWRVNDHKFTPLLCEIWDV
3D structure
PDB5y49 A moderator XD22 binding to bile acid receptor
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K313 H323 Q326 I327 L330 K331 L474 E477 K59 H69 Q72 I73 L76 K77 L217 E220
BS02 XD5 A F294 L297 T298 A301 F339 W464 F471 W479 F40 L43 T44 A47 F85 W207 F214 W222
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5y49, PDBe:5y49, PDBj:5y49
PDBsum5y49
PubMed
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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