Structure of PDB 5y3q Chain A

Receptor sequence
>5y3qA (length=317) [Search protein sequence]
MEVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVN
HEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVG
GLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCA
LILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL
TGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPA
EYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGP
VTDVFYKETSYTTTILE
3D structure
PDB5y3q Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C190 C193 C225 C227 C190 C193 C225 C227
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5y3q, PDBe:5y3q, PDBj:5y3q
PDBsum5y3q
PubMed29289665
UniProtP0C6U8|R1A_SARS Replicase polyprotein 1a (Gene Name=1a)

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