Structure of PDB 5y3m Chain A

Receptor sequence
>5y3mA (length=738) Species: 9913 (Bos taurus) [Search protein sequence]
LPAFLPCELQPHGQVDCNWLFLKSVPHFSAGAPRANVTSLSLISNRIHHL
HDSDFVHLSNLRVLNLKWNCPPAGLSPMHFPCRMTIEPNTFLAVPTLEEL
NLSYNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALRFLYMDGNC
YYMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPRRLPPSLDTLLLS
YNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCRECPKNFPKLHPD
TFSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITKTT
IFNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDMHGIFFRS
LTNITLQSLTRLPKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRIS
GAMPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGS
QFVPLTSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYNSQPFSMQGVG
HNLSFVAQLPSLRYLSLAHNGIHSRVSQKLSSASLRALDFSGNSLSQMWA
EGDLYLCFFKGLRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNL
AFFNWSSLTVLPRLEALDLAGNQLKALSNGSLPPGIRLQKLDVSSNSIGF
VIPGFFVRATRLIELNLSANALKTVDPSWFGSLAGTLKILDVSANPLHCA
CGAAFVDFLLERQEAVPGLSRRVTCGSPGQLQGRSIFT
3D structure
PDB5y3m Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D258 Y344 H345 K347 V348 S349 F350 A351 F374 R376 F401 D231 Y317 H318 K320 V321 S322 F323 A324 F347 R349 F374
BS02 dna A D532 Y534 G563 H564 R588 D469 Y471 G500 H501 R525
BS03 dna A W46 S71 R73 H75 H76 W95 P98 S103 P104 M105 F107 W19 S44 R46 H48 H49 W68 P71 S76 P77 M78 F80
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5y3m, PDBe:5y3m, PDBj:5y3m
PDBsum5y3m
PubMed29625894
UniProtQ5I2M5|TLR9_BOVIN Toll-like receptor 9 (Gene Name=TLR9)

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