Structure of PDB 5y3l Chain A

Receptor sequence
>5y3lA (length=750) Species: 9796 (Equus caballus) [Search protein sequence]
TLPPFLPCELQPHGLVNCNWLFLKSVPHFSAAAPRDNVTSLSLLSNRIHH
LHDSDFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIEPNTFLAVPTLEE
LNLSYNGITTVPALPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGN
CYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPRSLPPSLEYLLL
SYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHS
DTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKT
KAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFR
SLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRI
SGAVESEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNS
ISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQ
PFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCSTSLWALDFSG
NSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQL
LRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLD
VSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDV
SANPLHCACGAAFVDFLLQVQAAVPGLPSRVKCGSPGQLQGRSIFAQDLR
3D structure
PDB5y3l Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A W47 F49 S72 R74 W96 S104 P105 F108 Y180 K181 Y208 R262 N263 W20 F22 S45 R47 W69 S77 P78 F81 Y153 K154 Y181 R235 N236
BS02 dna A D259 Y345 K348 V349 S350 F351 A352 F375 R377 F402 D232 Y318 K321 V322 S323 F324 A325 F348 R350 F375
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5y3l, PDBe:5y3l, PDBj:5y3l
PDBsum5y3l
PubMed29625894
UniProtQ2EEY0|TLR9_HORSE Toll-like receptor 9 (Gene Name=TLR9)

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