Structure of PDB 5y3k Chain A

Receptor sequence

>5y3kA (length=750) Species: 9796 (Equus caballus)

TLPPFLPCELQPHGLVNCNWLFLKSVPHFSAAAPRDNVTSLSLLSNRIHH
LHDSDFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIEPNTFLAVPTLEE
LNLSYNGITTVPALPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGN
CYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPRSLPPSLEYLLL
SYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHS
DTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKT
KAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFR
SLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRI
SGAVESEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNS
ISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQ
PFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCSTSLWALDFSG
NSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQL
LRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLD
VSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDV
SANPLHCACGAAFVDFLLQVQAAVPGLPSRVKCGSPGQLQGRSIFAQDLR

3D structure

• PDB: 5y3k Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
• Chain: A
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	W47 F49 K51 S72 R74 K95 W96 P99 S104 P105 M106 F108 S131 S151 R152 Y173 D175 K207	W20 F22 K24 S45 R47 K68 W69 P72 S77 P78 M79 F81 S104 S124 R125 Y146 D148 K180
BS02	dna	A	Y345 H346 K348 V349 S350 F351 A352 F375 R377 F402	Y318 H319 K321 V322 S323 F324 A325 F348 R350 F375

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity

Biological Process

• GO:0002224 toll-like receptor signaling pathway
• GO:0006955 immune response

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5y3k, PDBe:5y3k, PDBj:5y3k
• PDBsum: 5y3k
• PubMed: 29625894
• UniProt: Q2EEY0|TLR9_HORSE Toll-like receptor 9 (Gene Name=TLR9)