Structure of PDB 5xze Chain A

Receptor sequence
>5xzeA (length=357) Species: 10090 (Mus musculus) [Search protein sequence]
KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPL
SHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLI
RNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLV
PKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECL
KLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSC
FDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERN
NGFPIFD
3D structure
PDB5xze Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
ChainA
Resolution2.177 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R158 L159 K160 R161 H203 N376 E386 K395 R10 L11 K12 R13 H55 N228 E238 K247
BS02 dna A S165 A168 N196 Y200 Y201 K372 S17 A20 N48 Y52 Y53 K224
BS03 ZN A H378 C384 C385 C392 H230 C236 C237 C244
BS04 AE7 A R364 L365 C419 H422 H467 R216 L217 C271 H274 H319
External links
PDB RCSB:5xze, PDBe:5xze, PDBj:5xze
PDBsum5xze
PubMed28963528
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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