Structure of PDB 5xz8 Chain A

Receptor sequence
>5xz8A (length=317) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence]
MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIH
KLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVI
GGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIG
LVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDI
KEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLG
HVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDE
IFDKFDYSLYELANKLS
3D structure
PDB5xz8 Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.11: 6-phosphofructokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F6P A R72 D129 M171 R173 E224 H251 R254 R72 D129 M171 R173 E224 H251 R254
BS02 ANP A S9 G10 G11 Y41 R72 C73 F76 G102 G104 S105 R107 G108 R173 S9 G10 G11 Y41 R72 C73 F76 G102 G104 S105 R107 G108 R173
Gene Ontology
Molecular Function
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
GO:0008443 phosphofructokinase activity
GO:0016208 AMP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
GO:0070095 fructose-6-phosphate binding
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0061621 canonical glycolysis
Cellular Component
GO:0005737 cytoplasm
GO:0005945 6-phosphofructokinase complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:5xz8, PDBe:5xz8, PDBj:5xz8
PDBsum5xz8
PubMed29940104
UniProtQ2FXM8|PFKA_STAA8 ATP-dependent 6-phosphofructokinase (Gene Name=pfkA)

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