Structure of PDB 5xyr Chain A

Receptor sequence
>5xyrA (length=1380) Species: 1314 (Streptococcus pyogenes) [Search protein sequence]
LPPVNTDIHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAHQSMRISDVST
AKVKSKEDMLARQKAAGINYGSWINDKVVFAHNYVENSDNIKENQDTKYE
SHGMHVTGIVAGNSKEAAATGERFLGIAPEAQVMFMRVFANDVMGSAESL
FIKAIEDAVALGADVINLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVVV
AAGNERVYGSDHDDPLATNPDYGLVGSPSTGRTPTSVAAINSKWVIQRLM
TVEELEKRADLNHGKAIYSESVDFKNIKDSHQFAYVKESTDAGYNAQDVK
GKIALIERDPNKTYDEMIALAKKHGALGVLIFNNKPGQSNRIPSAFISHE
FGKAMSQLNGNTGSLEFDSVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDI
TAPGGDIYSTYNDNHYGSQTGTSMASPQIAGASLLVKQYLEKTQPNLPKE
KIADIVKNLLMSNAQIHVNPETKTTTSPRQQGAGLLNIDGAVTSGLYVTG
KDNYGSISLGNITDTMTFDVTVHNLSNKDKTLRYDTELLTDHVDPQKGRF
TLTSRSLKTYQGGEVTVPANGKVTVRVTMDVSQFTKELTKQMPNGYYLEG
FVRFRDSQDDQLNRVNIPFVGFKGQFENLAVAEESIYRLKSQGKTGFYFD
ESGPKDDIYVGKHFTGLVTLGSETNVSTKTISDNGLHTLGTFKNADGKFI
LEKNAQGNPVLAISPNGDNNQDFAAFKGVFLRKYQGLKASVYHASDKEHK
NPLWVSPESFKGDKNFNSDIRFAKSTTLLGTAFSGKSLTGAELPDGYYHY
VVSYYPDVVGAKRQEMTFDMILDRQKPVLSQATFDPETNRFKPEPLKDRG
LAGVRKDSVFYLERKDNKPYTVTINDSYKYVSVEDNKTFVERQADGSFIL
PLDKAKLGDFYYMVEDFAGNVAIAKLGDHLPQTLGKTPIKLKLTDGNYQT
KETLKDNLEMTQSDTGLVTNQAQLAVVHRNQPQSQLTKMNQDFFISPNED
GNKDFVAFKGLENNVYNDLTVNVYAKDDHQKQTPIWSSQAGAGASAIEST
AWYGITARGSKVMPGDYQYVVTYRDEHGKEHQKQYTISVNDKKPMITQGR
FDTINGVDHFTPDKTKALGSSGIVREEVFYLAKKNGRKFDVTEGKDGITV
SDNKVYIPKNPDGSYTISKRDGVTLSDYYYLVEDRAGNVSFATLRDLKAV
GKDKAVVNFGLDLPVPEDKQIVNFTYLVRDADGKPIENLEYYNNSGNSLI
LPYGKYTVELLTYDTNAAKLESDKIVSFTLSADNNFQQVTFKMTMLATSQ
ITAHFDHLLPEGSRVSLKTAQGQLIPLEQSLYVPKAYGKTVQEGTYEVVV
SLPKGYRIEGNTKVNTLPNEVHELSLRLVK
3D structure
PDB5xyr Structure of ScpC, a virulence protease fromStreptococcus pyogenes, reveals the functional domains and maturation mechanism.
ChainA
Resolution2.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.21.110: C5a peptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A S1190 N1192 D1194 N1196 K1197 D1198 S996 N998 D1000 N1002 K1003 D1004
BS02 CA A N351 G400 L401 V402 N174 G223 L224 V225
BS03 CA A S908 N910 D912 N914 D916 S714 N716 D718 N720 D722
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005618 cell wall
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xyr, PDBe:5xyr, PDBj:5xyr
PDBsum5xyr
PubMed30049896
UniProtQ3HV58

[Back to BioLiP]