Structure of PDB 5xya Chain A

Receptor sequence
>5xyaA (length=1358) Species: 1314 (Streptococcus pyogenes) [Search protein sequence]
SLPPVNTDIHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAHQSMRISDVS
TAKVKSKEDMLARQKAAGINYGSWINDKVVFAHNYVENSDNIKENQFKYE
SHGMHVTGIVAGNSKEAAATGERFLGIAPEAQVMFMRVFANDVMGSAESL
FIKAIEDAVALGADVINLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVVV
AAGNERVYGSDHDDPLATNPDYGLVGSPSTGRTPTSVAAINSKWVIQRLM
TVEELEKRADLNHGKAIYSESVDFKNIKDSLGYDKSHQFAYVKESTDAGY
NAPNKTYDEMIALAKKHGIPSAFISHEFGKAMSQLNGNGTGSLEFDSVVS
KAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGGDIYSTYNDNHYGSQTGT
SMASPQIAGASLLVKQYLEKTQPNLPKEKIADIVKNLLMSNAQIHVNPET
KTTTSPRQQGAGLLNIDGAVTSGLYVTGKDNYGSISLGNITDTMTFDVTV
HNLSNKDKTLRYDTELLTDHVDPQKGRFTLTSRSLKTYQGGEVTVPANGK
VTVRVTMDVSQFTKELTKQMPNGYYLEGFVRFRDSQDDQLNRVNIPFVGF
KGQFENLAVAEESIYRLKSQGKTGFYFDESGPKDDIYVGKHFTGLVTLGS
ETNVSTKTISDNGLHTLGTFKNADGKFILEKNAQGNPVLAISPNGDNNQD
FAAFKGVFLRKYQGLKASVYHASDKEHKNPLWVSPESFKGDKNFNSDIRF
AKSTTLLGTAFSGKSLTGAELPDGYYHYVVSYYPDVVGAKRQEMTFDMIL
DRQKPVLSQATFDPETNRFKPEPLKDRGLAGVRKDSVFYLERKDNKPYTV
TINDSYKYVSVEDNKTFVERQADGSFILPLDKAKLGDFYYMVEDFAGNVA
IAKLGDHLPQTLGKTPIKLKLTDGNYQTKETLKDNLEMTQSDTGLVTNQA
QLAVVHRNQPQSQLTKMNQDFFISPNEDGNKDFVAFKGLENNVYNDLTVN
VYAKDDHQKQTPIWSSQAGAGASAIESTAWYGITARGSKVMPGDYQYVVT
YRDEHGKEHQKQYTISVNDKKPMITQGRFDTINGVDHFTPDKTKALGSSG
IVREEVFYLAKKNGRKFDVTEGKDGITVSDNKVYIPKNPDGSYTISKRDG
VTLSDYYYLVEDRAGNVSFATLRDLKAVGKDKAVVNFGLDLPVPEDKQIV
NFTYLVRDADGKPIENLEYYNNSGNSLILPYGKYTVELLTYDTNAAKLES
DKIVSFTLSADNNFQQVTFKMTMLATSQITAHFDHLLPEGSRVSLKTAQG
QLIPLEQSLYVPKAYGKTVQEGTYEVVVSLPKGYRIEGNTKVNTLPNEVH
ELSLRLVK
3D structure
PDB5xya Structure of ScpC, a virulence protease fromStreptococcus pyogenes, reveals the functional domains and maturation mechanism.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.110: C5a peptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AES A H279 N381 F579 T614 S617 H102 N204 F363 T398 S401
BS02 CA A S1190 N1192 D1194 N1196 D1198 S974 N976 D978 N980 D982
BS03 CA A D1017 Q1019 D1042 R1043 D1110 D801 Q803 D826 R827 D894
BS04 CA A S908 N910 D912 N914 D916 S692 N694 D696 N698 D700
BS05 CA A Y936 H937 D940 Y720 H721 D724
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005618 cell wall
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xya, PDBe:5xya, PDBj:5xya
PDBsum5xya
PubMed30049896
UniProtQ3HV58

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