Structure of PDB 5xxz Chain A

Receptor sequence
>5xxzA (length=1334) Species: 1314 (Streptococcus pyogenes) [Search protein sequence]
SLPPVNTDIHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAHQSMRISDVS
TAKVKSKEDMLARQKAAGINYGSWINDKVVFAHNYVENSSAGMHVTGIVA
GNSKEAAATGERFLGIAPEAQVMFMRVFANDVMGSAESLFIKAIEDAVAL
GADVINLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVVVAAGNERVYGSD
HDDPLATNPDYGLVGSPSTGRTPTSVAAINSKWVIQRLMTVEELEKRADL
NHGKAIYSESVDFKNIKDSLGYDKSHQFAYVKESTDAQDVKGKIALIERD
PNKYDEMIALAKKHGALGVLIFIPSAFISHEFGKAMSQLNGNGTGSLEFD
SVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGQTGTAMASPQIAGA
SLLVKQYLEKTQPNLPKEKIADIVKNLLMSNAQIHVNPETKTTTSPRQQG
AGLLNIDGAVTSGLYVTGKDNYGSISLGNITDTMTFDVTVHNLSNKDKTL
RYDTELLTDHVDPQKGRFTLTSRSLKTYQGGEVTVPANGKVTVRVTMDVS
QFTKELTKQMPNGYYLEGFVRFRDSQDDQLNRVNIPFVGFKGQFENLAVA
EESIYRLKSQGKTGFYFDESGPKDDIYVGKHFTGLVTLGSETNVSTKTIS
DNGLHTLGTFKNADGKFILEKNAQGNPVLAISPNGDNNQDFAAFKGVFLR
KYQGLKASVYHASDKEHKNPLWVSPESFKGDKNFNSDIRFAKSTTLLGTA
FSGKSLTGAELPDGYYHYVVSYYPDVVGAKRQEMTFDMILDRQKPVLSQA
TFDPETNRFKPEPLKDRGLAGVRKDSVFYLERKDNKPYTVTINDSYKYVS
VEDNKTFVERQADGSFILPLDKAKLGDFYYMVEDFAGNVAIAKLGDHLPQ
TLGKTPIKLKLTDGNYQTKETLKDNLEMTQSDTGLVTNQAQLAVVHRNQP
QSQLTKMNQDFFISPNEDGNKDFVAFKGLENNVYNDLTVNVYAKDDHQKQ
TPIWSSQAGAGASAIESTAWYGITARGSKVMPGDYQYVVTYRDEHGKEHQ
KQYTISVNDKKPMITQGRFDTINGVDHFTPDKTKALGSSGIVREEVFYLA
KKNGRKFDVTEGKDGITVSDNKVYIPKNPDGSYTISKRDGVTLSDYYYLV
EDRAGNVSFATLRDLKAVGKDKAVVNFGLDLPVPEDKQIVNFTYLVRDAD
GKPIENLEYYNNSGNSLILPYGKYTVELLTYDTNAAKLESDKIVSFTLSA
DNNFQQVTFKMTMLATSQITAHFDHLLPEGSRVSLKTAQGQLIPLEQSLY
VPKAYGKTVQEGTYEVVVSLPPNEVHELSLRLVK
3D structure
PDB5xxz Structure of ScpC, a virulence protease fromStreptococcus pyogenes, reveals the functional domains and maturation mechanism.
ChainA
Resolution3.085 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.110: C5a peptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A S374 T412 S627 K651 S186 T224 S401 K425
BS02 CA A D1017 Q1019 D1042 R1043 D1110 D791 Q793 D816 R817 D884
BS03 CA A S908 N910 D912 N914 D916 S682 N684 D686 N688 D690
BS04 CA A S1190 N1192 D1194 N1196 D1198 S964 N966 D968 N970 D972
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005618 cell wall
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xxz, PDBe:5xxz, PDBj:5xxz
PDBsum5xxz
PubMed30049896
UniProtQ3HV58

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