Structure of PDB 5xxk Chain A

Receptor sequence
>5xxkA (length=95) Species: 9606 (Homo sapiens) [Search protein sequence]
QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIATKRLY
DEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQ
3D structure
PDB5xxk Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.
ChainA
Resolution1.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L54 F55 G58 I61 Q72 H73 F86 V93 H96 Y100 L37 F38 G41 I44 Q55 H56 F69 V76 H79 Y83
BS02 peptide A I19 F55 Y56 Q59 I2 F38 Y39 Q42
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:5xxk, PDBe:5xxk, PDBj:5xxk
PDBsum5xxk
PubMed29228061
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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