Structure of PDB 5xww Chain A

Receptor sequence

>5xwwA (length=477) Species: 40318 (Streptomyces nodosus) [Search protein sequence]

GSHMDALRYHIEWNRVAEPGTARPAGRLLAVISPDHAGAPWVTAVLDALG
PDTVRFEAKGTDRAAWAAQLAQLREDEGEFHAVVSLLAAAEALHTDHGSV
PLGLAQTLLLAQALGDAGLTAPLWCLTRGGVAAGRGDVLSSPVQGALWGL
GRVIGLEHPDRWGGLIDLPETVDTRAAARLTGLLADAGGEDQLAIRGSGV
LARRLAHAAPAVPGSGKRPPVHGSVLVTGGTGGIGGRVARRLAEQGAAHL
VLTSRRGADAPGAAELRAELEQLGVRVTIAACDAADREALAALLAELPED
APLTAVFHSAGVAHDDAPVADLTLGQLDALMRAKLTAARHLHELTADLDL
DAFVLFSSTAAVWGSGGHPGYAAANAYLDALAEHRRSLGLTASSVAWGTW
GEVGMATDPEVHDRLVRQGVLAMEPEHALGALDQMLENDDTAAAITLMDW
EMFAPAFTANRPSALLSTVPEAVSALS

3D structure

PDB

5xww Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.

Chain

Resolution

1.96 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	G225 G228 G229 I230 S250 R251 R252 D279 A280 S305 A306 G307 K330 S353 S354 Y367 W393 G394 T395 G400 M401	G229 G232 G233 I234 S254 R255 R256 D283 A284 S309 A310 G311 K334 S357 S358 Y371 W397 G398 T399 G404 M405
BS02	8H6	A	L152 S354 T355 A356 W359 G362 L411 Q414 F449 F453	L156 S358 T359 A360 W363 G366 L415 Q418 F453 F457

External links

PDB	RCSB:5xww, PDBe:5xww, PDBj:5xww
PDBsum	5xww
PubMed	29626512
UniProt	Q93NW7

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