Structure of PDB 5xw2 Chain A

Receptor sequence
>5xw2A (length=375) Species: 457427 (Streptomyces himastatinicus ATCC 53653) [Search protein sequence]
MTTPAERWGIHPEHFWLYGRRPRQMVEFDEKMNAWNVYGYAEAIEVLGDP
GTFSSHMSRLLPMGAAFTEGDLLQTDPPDHRELRKLVSHAFTPKVVAELE
PRITALTQELLDAVADRDTFDLMTALAYPLPVTVVAELLSIPSADRHLFE
GWMTEIVHSLGAPMRKMLEYLREHAAECRRRPRGDLMGKLIEAERRLTDN
HIVNFAKMLLIAGYLTTTMLIGNTVLCLDSYPEQAARVRADRSLIPGLLE
ESMRFLSPVAATYRATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEP
ELFDMTRGPNPHLGFGRGIHFCLGGPLARMEGRVALDHLLDRFPELYTDP
ERPPTFMPGFDTTGVSSLPLRTSLG
3D structure
PDB5xw2 Molecular characterization of the hydroxylase HmtN at 1.3 angstrom resolution.
ChainA
Resolution1.298 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H160 A236 L239 T240 T241 C346 L347 G348 E355 T386
Catalytic site (residue number reindexed from 1) H158 A212 L215 T216 T217 C322 L323 G324 E331 T362
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A L74 L75 H82 R86 F93 A236 G237 T240 T286 R288 G338 F339 H344 C346 G348 A352 L72 L73 H80 R84 F91 A212 G213 T216 T262 R264 G314 F315 H320 C322 G324 A328
BS02 MG A R59 T290 R59 T266
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5xw2, PDBe:5xw2, PDBj:5xw2
PDBsum5xw2
PubMed28687492
UniProtD9WMQ6

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