Structure of PDB 5xvq Chain A

Receptor sequence
>5xvqA (length=252) Species: 9544 (Macaca mulatta) [Search protein sequence]
FTSKDTYLRHFNPRDYLEKYYKSAESQILKHLLENLFKIFCLDGVKGDLL
IDIGSGPTIYQLLSACESFKEIIVTDYSDQNLQELEKWLKKEPEAFDWSP
VVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPLADC
LLSTLCLDAACPDLPTYRRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQ
KFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVGRK
LS
3D structure
PDB5xvq Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
ChainA
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y11 Y20 Y25 G63 S64 G65 T67 Y69 D85 Y86 N90 D142 V143 T163 L164 C165 A169 Y7 Y16 Y21 G54 S55 G56 T58 Y60 D76 Y77 N81 D133 V134 T154 L155 C156 A160
BS02 8GC A Y20 L164 A198 S201 Y204 S213 Y242 Y16 L155 A189 S192 Y195 S204 Y233 MOAD: ic50=9uM
PDBbind-CN: -logKd/Ki=5.05,IC50=9uM
Gene Ontology
Molecular Function
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006769 nicotinamide metabolic process
GO:0032259 methylation
GO:0045722 positive regulation of gluconeogenesis
GO:0090312 positive regulation of protein deacetylation
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:5xvq, PDBe:5xvq, PDBj:5xvq
PDBsum5xvq
PubMed28720493
UniProtF7ERX8

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