Structure of PDB 5xve Chain A

Receptor sequence
>5xveA (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
AQGLAGLRNLGNTSFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHT
ALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFL
RFLLDGLHNEVNRVTLENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQ
LKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVL
DGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTF
VNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTG
EWHTFNDSSVTPMSSSQVRTSDAYLLFYELA
3D structure
PDB5xve 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2
ChainA
Resolution1.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C425 C428 C476 C479 C157 C160 C208 C211
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5xve, PDBe:5xve, PDBj:5xve
PDBsum5xve
PubMed29449607
UniProtO75604|UBP2_HUMAN Ubiquitin carboxyl-terminal hydrolase 2 (Gene Name=USP2)

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