Structure of PDB 5xr8 Chain A

Receptor sequence

>5xr8A (length=431) Species: 882,9606

FMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRP
SYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFT
ASVGSLFLAAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLP
LLGWNCEKLQSVCSDIFPHIDKTYLMFWIGVVSVLLLFIVYAYMYILWKA
HSHAVAKALIVYGSTTGNTEYTAETIARELADAGYEVDSRDAASVEAGGL
FEGFDLVLLGCSTWGDDSIELQDDFIPLFDSLEETGAQGRKVACFGCGDS
SWEYFCGAVDAIEEKLKNLGAEIVQDGLRIDGDPRAARDDIVGWAHDVRG
AIRMDIELAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCS
MLCLLNSTVNPIIYALRSKDLRHAFRSMFPS

3D structure

• PDB: 5xr8 Crystal structures of agonist-bound human cannabinoid receptor CB1.
• Chain: A
• Resolution: 2.95 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FMN	A	S315 T316 T317 G318 N319 T320 S363 T364 W365 G366 D367 C398 G399 D400 W403 Y405 F406	S214 T215 T216 G217 N218 T219 S262 T263 W264 G265 D266 C297 G298 D299 W302 Y304 F305
BS02	8D0	A	F174 F177 F189 L193 T197 I267 F268 I271 W279 F501 S505	F73 F76 F88 L92 T96 I166 F167 I170 W178 F396 S400
BS03	CLR	A	H154 S158 W241 I245	H53 S57 W140 I144

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004949 cannabinoid receptor activity
• GO:0009055 electron transfer activity
• GO:0010181 FMN binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5xr8, PDBe:5xr8, PDBj:5xr8
• PDBsum: 5xr8
• PubMed: 28678776
• UniProt: P00323|FLAV_NITV2 Flavodoxin (Gene Name=DVU_2680);
  P21554|CNR1_HUMAN Cannabinoid receptor 1 (Gene Name=CNR1)