Structure of PDB 5xpm Chain A

Receptor sequence
>5xpmA (length=239) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRSPLSMLPHLADLVS
YSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMS
WDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMA
ICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQ
KLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
3D structure
PDB5xpm Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 S252 I256 L259 K260 P412 E416 I57 K61 S71 I75 L78 K79 P231 E235
BS02 8C0 A Y143 V230 S233 R270 S271 S274 W282 C284 A299 H301 L305 H393 L400 Y21 V49 S52 R89 S90 S93 W101 C103 A118 H120 L124 H212 L219 MOAD: ic50=23nM
PDBbind-CN: -logKd/Ki=7.64,IC50=23nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5xpm, PDBe:5xpm, PDBj:5xpm
PDBsum5xpm
PubMed28954197
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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