Structure of PDB 5xpi Chain A

Receptor sequence
>5xpiA (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]
WDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKEDVIYHVKYDDYPE
NGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEI
SRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERP
3D structure
PDB5xpi Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8C3 A D145 M148 F152 Y188 Y191 N194 F237 D19 M22 F26 Y45 Y48 N51 F94 MOAD: Kd=5.2uM
PDBbind-CN: -logKd/Ki=5.28,Kd=5.2uM
External links
PDB RCSB:5xpi, PDBe:5xpi, PDBj:5xpi
PDBsum5xpi
PubMed29562800
UniProtQ96T88|UHRF1_HUMAN E3 ubiquitin-protein ligase UHRF1 (Gene Name=UHRF1)

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