Structure of PDB 5xmx Chain A

Receptor sequence
>5xmxA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
VADLKAFSKHIYNAYLKNFNMTKKKARSILTGAPFVIHDIETLWQAEKGL
VWGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTL
LKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPK
FEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRAL
EFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHP
LLQEIYK
3D structure
PDB5xmx Novel highly selective peroxisome proliferator-activated receptor delta (PPAR delta) modulators with pharmacokinetic properties suitable for once-daily oral dosing.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 89L A F246 C249 T252 T253 H287 L294 L303 V305 V312 I328 H413 Y437 F65 C68 T71 T72 H106 L113 L122 V124 V131 I147 H232 Y256 PDBbind-CN: -logKd/Ki=7.24,Kd=57nM
BindingDB: EC50=37nM,Kd=57nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xmx, PDBe:5xmx, PDBj:5xmx
PDBsum5xmx
PubMed29103972
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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