Structure of PDB 5xjb Chain A

Receptor sequence
>5xjbA (length=341) Species: 10090 (Mus musculus) [Search protein sequence]
PNWEFARMIKEFRVTMECSPLTVTDPIEEHRICVCVRKRPLNKQELAKKE
IDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRF
TARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGQNASKGIYAMASRDVFL
LKNQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSRQQVQVVG
LQEYLVTCADDVIKMINMGSACRTSGQSSRSHACFQILLRTKGRLHGKFS
LVDLAGNERGADRMEGAEINKSLLALKECIRALGQNKHTPFRESKLTQVL
RDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELS
3D structure
PDB5xjb Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R262 P263 T346 G347 G349 K350 T351 H352 R39 P40 T123 G124 G126 K127 T128 H129
BS02 BEF A K350 R452 S463 S464 S466 D488 L489 K127 R223 S228 S229 S231 D253 L254
BS03 MG A T351 S463 T128 S228
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:5xjb, PDBe:5xjb, PDBj:5xjb
PDBsum5xjb
PubMed28903043
UniProtQ922S8|KIF2C_MOUSE Kinesin-like protein KIF2C (Gene Name=Kif2c)

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