Structure of PDB 5xja Chain A

Receptor sequence
>5xjaA (length=337) Species: 10090 (Mus musculus) [Search protein sequence]
PNWEFARMIKEFRVTMECSPLTVTDPIEEHRICVCVRKRPLNKQELAKKE
IDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRF
TARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLQNASKGIYAMASRDV
FLLKNQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSRQQVQV
VGLQEYLVTCADDVIKMINMGSACRTSSRSHACFQILLRTKGRLHGKFSL
VDLAGNERGARQTRMEGAEINKSLLALKECIRALGQFRESKLTQVLRDSF
IGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELS
3D structure
PDB5xja Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation
ChainA
Resolution3.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R262 P263 T346 G347 G349 K350 T351 H352 L358 R39 P40 T123 G124 G126 K127 T128 H129 L135
BS02 AF3 A T351 S463 D488 T128 S227 D252
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:5xja, PDBe:5xja, PDBj:5xja
PDBsum5xja
PubMed28903043
UniProtQ922S8|KIF2C_MOUSE Kinesin-like protein KIF2C (Gene Name=Kif2c)

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