Structure of PDB 5xio Chain A

Receptor sequence
>5xioA (length=474) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
MGITADKITSFADWYSQVIVKSEMIEYYDISGCYILRPWSYFIWETIQSV
FDQKIKQHDVQNAYFPIFVTQKKLETEFSPEVAWVTKSGKSDLAEPIAIR
PTSETIMYPYFAKWIRSHRDLPLKINQWTSIVRWEFKHPTPFIRTREFLW
QEGHTAHSTRKEALEMVDIILNEYASIYEDLLATPVVKGTKSENEKFPGG
DITKSIEGFIPEIGRAVQAATSHLLGQNFSKMFGVEFEDEKGNKEYAHQT
SWGLTTRAIGVMIMTHGDNKGLVLPPKVAPVQVIIIPITEEQKKICNEVE
CILKKAGVRVKIDDRSNYTPGWKYNHWEVKGVCLRFEVGPRDIEKRSVRV
VVRDNMEKMDIPISELESKIPKLLEEFQNRLLFKAKQRQNESIIRVDTFD
KVMDTLNQKKMVIAPWCEDVSCEEEIKKETARLSGAMKSLCIPNDQIFKI
EEGKTKCFFCDKLAKKFTLFGRSY
3D structure
PDB5xio Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
ChainA
Resolution2.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HFG A F307 E310 V311 T331 E333 R362 W379 F426 F78 E81 V82 T102 E104 R133 W150 F197
BS02 ZN A C652 C657 C702 C705 C417 C422 C457 C460
BS03 ANP A R362 E364 I372 T374 F377 Q447 T484 R486 R133 E135 I143 T145 F148 Q218 T255 R257
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xio, PDBe:5xio, PDBj:5xio
PDBsum5xio
PubMed28867614
UniProtQ5CWN3

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