Structure of PDB 5xil Chain A

Receptor sequence
>5xilA (length=445) Species: 5664 (Leishmania major) [Search protein sequence]
MGIAAKREENFSAWYIDVITKAEMIEYYIIRPWAYYVWKCVQRFLGGKIE
KLGVEDCYFPTSETVMYPYYAKWIRSHRDLPVRLNMWNNVIPTPFIRTRE
FLWQEGHCAWAKAEECAKEVLEILECYASVYEQLLAVPVVRGRKTEKEKF
AGGDYTTTVETFIEAVGRGCQGATSHNLGQNFGKMFDIRFQDPENNEQTL
IPWQNSWGLSTRVIGVMIMVHGDNRGMVMPPRVASTQVIIIPVGITKDTT
EEARQELLASCWRLESELCEGGVRARCDLRDNYSPGWRFNHWEVKGVPLR
VELGPRELAERSLAVAVRHSGARHSVAWDAQTPAAVAALLEDVHAQMYAR
AKETMETHRVRVTEWTEFVPTLNRKCLILAPWCGAMECENQVKKDSAEES
KAPSMGAKTLCIPFEQPEEPAEGHECICKGCTKPATTWVLFGRSY
3D structure
PDB5xil Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C687 C692 C737 C383 C388 C426
BS02 MG A E468 H662 E164 H358
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xil, PDBe:5xil, PDBj:5xil
PDBsum5xil
PubMed28867614
UniProtQ4QDS0

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