Structure of PDB 5xig Chain A

Receptor sequence
>5xigA (length=486) Species: 508771 (Toxoplasma gondii ME49) [Search protein sequence]
AMVTAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQRF
FDDEIKKMGVENSYFPMFVSRHKLEKEGFSPEVAWVTHYGDSPLPEKIAI
RPTSETIMYPAYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRTREFL
WQEGHTAHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAG
GKKTTTVEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKRLVHQ
TSWGCTTRSLGVMIMTHGDDKGLVIPPRVASVQVVIIPILFKDENTGEIL
GKCRELKTMLEKADIRVRIDDRSNYTPGWKYNHWEVKGVPLRLELGPKDL
AKGTARVVRRDTGEAYQISWADLAPKLLELMEGIQRSLFEKAKARLHEGI
EKISTFDEVMPALNRKHLVLAPWCEDPESEEQIKKETQKLSEIQAIETGA
MKTLCIPFDQPPMPEGTKCFYTGKPAKRWTLWGRSY
3D structure
PDB5xig Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
ChainA
Resolution2.41 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A R470 E472 R481 T482 F485 Q555 T592 R594 R134 E136 R145 T146 F149 Q219 T256 R258
BS02 87F A F415 P438 T439 E441 R470 W487 F534 H560 W589 F79 P102 T103 E105 R134 W151 F198 H224 W253 MOAD: ic50=350nM
PDBbind-CN: -logKd/Ki=6.38,IC50=420nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xig, PDBe:5xig, PDBj:5xig
PDBsum5xig
PubMed28867614
UniProtS8G8I1

[Back to BioLiP]