Structure of PDB 5xhs Chain A

Receptor sequence
>5xhsA (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
PSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDL
ATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRV
VVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALS
GKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEV
DRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTFRFHFQ
GPCGTTLPEALA
3D structure
PDB5xhs Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design
ChainA
Resolution2.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P68 T69 F70 R71 N141 D143 H158
Catalytic site (residue number reindexed from 1) P33 T34 F35 R36 N106 D108 H123
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SLL A Y102 R105 H158 V221 Y255 Y67 R70 H123 V186 Y220 PDBbind-CN: -logKd/Ki=5.05,Kd=9.01uM
BS02 MCM A E225 N226 L227 L232 E190 N191 L192 L197 PDBbind-CN: -logKd/Ki=5.05,Kd=9.01uM
BS03 ZN A C166 C169 C207 C212 C131 C134 C172 C177
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5xhs, PDBe:5xhs, PDBj:5xhs
PDBsum5xhs
PubMed
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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