Structure of PDB 5xgk Chain A

Receptor sequence

>5xgkA (length=368) Species: 3702 (Arabidopsis thaliana)

FSKFVRKNPKSDKFKVKRFHHIEFWCGDATNVARRFSWGLGMRFSAKSDL
STGNMVHASYLLTSGDLRFLFTAPYSPSPTTTASIPSFDHGSCRSFFSSH
GLGVRAVAIEVEDAESAFSISVANGAIPSSPPIVLNEAVTIAEVKLYGDV
VLRYVSFLPGFERVEDPLDYGIRRLDHAVGNVPELGPALTYVAGFTGFHQ
FAEFTSGLNSAVLASNDEMVLLPINEPVKSQIQTYLEHNEGAGLQHLALM
SEDIFRTLREMRKRSSIGGFDFMPSPPPTYYQNLKKRVGDVLSDDQIKEC
EELGILVDRDDQGTLLQIFTKPLGDRPTIFIEIIQRVGCMMYQSGGCGGF
GKGNFSELFKSIEEYEKT

3D structure

• PDB: 5xgk Crystal Structure of 4-Hydroxyphenylpyruvate Dioxygenase in Complex with Substrate Reveals a New Starting Point for Herbicide Discovery.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TYF	A	H226 V228 H308 Q379 F381 E394 F419 G420 N423	H177 V179 H246 Q317 F319 E332 F350 G351 N354
BS02	FE	A	H226 H308 E394	H177 H246 E332

Gene Ontology

Molecular Function

• GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity
• GO:0005506 iron ion binding
• GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0006559 L-phenylalanine catabolic process
• GO:0006572 tyrosine catabolic process
• GO:0009072 aromatic amino acid metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5xgk, PDBe:5xgk, PDBj:5xgk
• PDBsum: 5xgk
• PubMed: 31549053
• UniProt: P93836|HPPD_ARATH 4-hydroxyphenylpyruvate dioxygenase (Gene Name=HPD)