Structure of PDB 5xfj Chain A

Receptor sequence
>5xfjA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPLDPLWEFPRDRLVLGKPLGEGAFGQVVRAEAFGMDPARPDQASTVAV
KMLKDDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIMECAAK
GNLREFLRARRPPGPPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARN
VLVTEDNVMKIADFGLLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT
LGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRP
TFKQLVEALDKVLLAV
3D structure
PDB5xfj LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
ChainA
Resolution3.25 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D612 R616 N617 D630
Catalytic site (residue number reindexed from 1) D145 R149 N150 D163
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6LF A L473 E475 K503 A553 A554 G556 N557 L619 L21 E23 K51 A98 A99 G101 N102 L152 BindingDB: IC50=6.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5xfj, PDBe:5xfj, PDBj:5xfj
PDBsum5xfj
PubMed30298149
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

[Back to BioLiP]