Structure of PDB 5xez Chain A

Receptor sequence
>5xezA (length=545) Species: 9606,10665 [Search protein sequence]
QVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTT
ANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGE
EIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAI
HANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRV
AAVFMQYGIVANYCWLLVEGLYLHNLLGLANIFEMLRIDEGLRLKIYKDT
EGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNITKDEAEKLFNQDVDAAV
RGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKR
WDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYERSFFSLYLGIGWG
APMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFV
RIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHA
QGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRW
3D structure
PDB5xez Structure of the full-length glucagon class B G-protein-coupled receptor.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E240 D249
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 97V A R346 L347 K349 S350 T353 L399 L403 N404 R473 L474 K476 S477 T480 L526 L530 N531
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xez, PDBe:5xez, PDBj:5xez
PDBsum5xez
PubMed28514451
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P47871|GLR_HUMAN Glucagon receptor (Gene Name=GCGR)

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