Structure of PDB 5xdu Chain A

Receptor sequence

>5xduA (length=306) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252) [Search protein sequence]

HMATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESKI
QIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGGT
GTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAVD
TLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVNL
DFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQG
VLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVVT
VIATGF

3D structure

PDB

5xdu Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GDP	A	G20 G21 G22 N25 G104 G107 G110 E139 R143 N166 F183	G11 G12 G13 N16 G95 G98 G101 E130 R134 N157 F174
BS02	CA	A	L200 V203 N208 L209	L191 V194 N199 L200
BS03	ZI6	A	G193 G196 I197 D199 L200 V203 G205 N208 L209 M218 L261 N263 V297 T309 V310 I311	G184 G187 I188 D190 L191 V194 G196 N199 L200 M209 L252 N254 V288 T300 V301 I302

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005525	GTP binding

View graph for
Molecular Function

External links

PDB	RCSB:5xdu, PDBe:5xdu, PDBj:5xdu
PDBsum	5xdu
PubMed	28621933
UniProt	Q6GHP9\|FTSZ_STAAR Cell division protein FtsZ (Gene Name=ftsZ)

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