Structure of PDB 5xdt Chain A

Receptor sequence

>5xdtA (length=306) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252) [Search protein sequence]

HMATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESKI
QIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGGT
GTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAVD
TLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVNL
DFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQG
VLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVVT
VIATGF

3D structure

PDB

5xdt Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ

Chain

Resolution

1.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GDP	A	G20 G21 G22 N25 G104 G108 T109 G110 P135 E139 R143 N166 F183	G11 G12 G13 N16 G95 G99 T100 G101 P126 E130 R134 N157 F174
BS02	CA	A	L200 V203 N208 L209	L191 V194 N199 L200
BS03	ZI7	A	G193 G196 I197 D199 L200 V203 N208 L209 M218 L261 N263 V297 I311	G184 G187 I188 D190 L191 V194 N199 L200 M209 L252 N254 V288 I302
BS04	MB3	A	G22 T102 S103 G104 T133	G13 T93 S94 G95 T124

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005525	GTP binding

View graph for
Molecular Function

External links

PDB	RCSB:5xdt, PDBe:5xdt, PDBj:5xdt
PDBsum	5xdt
PubMed	28621933
UniProt	Q6GHP9\|FTSZ_STAAR Cell division protein FtsZ (Gene Name=ftsZ)

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