Structure of PDB 5xco Chain A

Receptor sequence
>5xcoA (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
SMTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKEK
3D structure
PDB5xco Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d
ChainA
Resolution1.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q61 E62 E63 R68 D69 M72 R73 H95 Y96 Q99 R102 V103 Q62 E63 E64 R69 D70 M73 R74 H96 Y97 Q100 R103 V104
BS02 GDP A G13 G15 K16 S17 A18 F28 V29 D30 T35 N116 K117 D119 L120 S145 A146 K147 G14 G16 K17 S18 A19 F29 V30 D31 T36 N117 K118 D120 L121 S146 A147 K148
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5xco, PDBe:5xco, PDBj:5xco
PDBsum5xco
PubMed28740607
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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