Structure of PDB 5x94 Chain A

Receptor sequence
>5x94A (length=206) Species: 9606 (Homo sapiens) [Search protein sequence]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTH
IKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN
CADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRT
GSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLK
QPLNTT
3D structure
PDB5x94 Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E17 R32 S34 S36 T42 T52 H53 I54 K55 G67 G68 K89 E90 E14 R29 S31 S33 T39 T49 H50 I51 K52 G64 G65 K86 E87
BS02 peptide A K120 R138 V148 H169 V181 G182 G183 M202 V203 E204 T205 K117 R135 V145 H156 V168 G169 G170 M189 V190 E191 T192
External links
PDB RCSB:5x94, PDBe:5x94, PDBj:5x94
PDBsum5x94
PubMed28930683
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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