Structure of PDB 5x8n Chain A

Receptor sequence
>5x8nA (length=425) Species: 10090 (Mus musculus) [Search protein sequence]
TVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIP
KFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLA
SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLA
CGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSC
WAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVT
GTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQ
VVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGII
EPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDK
IEALQRHENESVYKASLNLIEKYFS
3D structure
PDB5x8n Crystal structure of importin-alpha bound to the nuclear localization signal of Epstein-Barr virus EBNA-LP protein
ChainA
Resolution2.15 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L104 S105 R106 P110 W142 N146 S149 G150 T151 S152 Q181 W184 N188 G191 D192 N228 W231 S234 N235 R238 Y277 L32 S33 R34 P38 W70 N74 S77 G78 T79 S80 Q109 W112 N116 G119 D120 N156 W159 S162 N163 R166 Y205
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5x8n, PDBe:5x8n, PDBj:5x8n
PDBsum5x8n
PubMed28383161
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

[Back to BioLiP]