Structure of PDB 5x86 Chain A

Receptor sequence
>5x86A (length=188) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
PGLFLTLEGLDGSGKTTQARRLAAFLEAQGRPVLLTREPGGGLPEVRSLL
LTQELSPEAEYLLFSADRAEHVRKVILPGLAAGKVVISDRYLDSSLAYQG
YGRGLPLPWLREVAREATRGLKPRLTFLLDLPPEAALEGLGLEFFRRVRE
GYLALARAEPGRFVVLDATLPEEEIARAIQAHLRPLLP
3D structure
PDB5x86 Structural and functional roles of dynamically correlated residues in thymidylate kinase.
ChainA
Resolution1.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A Y62 S66 R69 Y61 S65 R68
BS02 MG A T7 E9 D94 T6 E8 D93
BS03 TMP A D12 R38 E39 P40 R48 F65 R69 R91 S95 S96 Y99 Q100 D11 R37 E38 P39 R47 F64 R68 R90 S94 S95 Y98 Q99
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5x86, PDBe:5x86, PDBj:5x86
PDBsum5x86
PubMed29652261
UniProtQ5SHX3|KTHY_THET8 Thymidylate kinase (Gene Name=tmk)

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