Structure of PDB 5x7j Chain A

Receptor sequence
>5x7jA (length=187) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
PGLFLTLEGLDGSGKTTQARRLAAFLEAQGRPVLLTREPGGGLPEVRSLQ
ELSPEAEYLLFSADRAEHVRKVILPGLAAGKVVISDRYLDSSLAYQGYGR
GLPLPWLREVAREATRGLKPRLTFLLDLPPEAALRRVRLGLEFFRRVREG
YLALARAEPGRFVVLDATLPEEEIARAIQAHLRPLLP
3D structure
PDB5x7j Insights into product release dynamics through structural analyses of thymidylate kinase.
ChainA
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A G15 T17 T18 G14 T16 T17
BS02 CA A G10 L11 L130 L132 G9 L10 L126 L128
BS03 CA A Y62 S66 R69 A115 Y58 S62 R65 A111
BS04 CA A T7 E9 D94 T127 T6 E8 D90 T123
BS05 CA A Q19 R22 L23 I189 Q18 R21 L22 I178
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5x7j, PDBe:5x7j, PDBj:5x7j
PDBsum5x7j
PubMed30447376
UniProtQ5SHX3|KTHY_THET8 Thymidylate kinase (Gene Name=tmk)

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