Structure of PDB 5x6r Chain A

Receptor sequence

>5x6rA (length=374) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

MSESVAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTLKSINLAIS
ARGIDALKSIDPDACEHILQDMIPMKGRMIHDLKGRQESQLYINSINRSV
LNNSLLDELEKSTTELKFGHKLVKIEWTDDKQICHFAITPHTEKYDFVIG
CDGAYSATRSQMQRKVEMDFSQEYMNLRYIELYIPPTEEFKPNYGGNFAI
APDHLHIWPRHKFMLIALANSDGSFTSTFFGSKDQISDLITSKSRVREFL
IENFPDIINIMDLDDAVKRFITYPKESLVCVNCKPYDVPGGKAILLGDAA
HAMVPFYGQGMNCGFEDVRILMALLKKHSGDRSRAFTEYTQTRHKDLVSI
TELAKRNYKEMSHDVTSKRFLLRK

3D structure

PDB

5x6r Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

Chain

Resolution

1.911 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.9: kynurenine 3-monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G9 V13 D32 F33 R34 K48 S49 L52 A53 R109 K132 L133 D168 G169 Y195 G313 D314 Q325 G326 M327 N328	G9 V13 D32 F33 R34 K43 S44 L47 A48 R98 K121 L122 D152 G153 Y179 G297 D298 Q309 G310 M311 N312
BS02	7ZR	A	A53 R83 I232 F246 F322 Q325 N373 M377	A48 R78 I216 F230 F306 Q309 N357 M361

Gene Ontology

	Molecular Function
GO:0071949	FAD binding

View graph for
Molecular Function

External links

PDB	RCSB:5x6r, PDBe:5x6r, PDBj:5x6r
PDBsum	5x6r
PubMed	29429898
UniProt	P38169\|KMO_YEAST Kynurenine 3-monooxygenase (Gene Name=BNA4)

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