Structure of PDB 5x62 Chain A

Receptor sequence
>5x62A (length=376) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
NQRENKAVARVIISFLKYEEYALKEIYNLRVKKWASISDRQKDMVPNYTK
YLANLKAAIIENGKFFRSVAEYALQSISFEPGEIVQPNDLDMSKTCSLLT
QVYREWSAEAISERNCLNSRLVPFLKTLSPPKADILIPGCGTGRLLVDLS
RMGYNCEGNEFSYHMLLVSQYMLNAGLLQNQIIIYPFIHCFSHWKKIEDQ
LSPIKVPDIEAWMGSMSICAGSFVDCYGRNQGTKISSHYTFSRRMQLSRA
KAENSKDVVVTNFFIDTGSNILDYLDTIGHVLKPGGIWCNFGPLLYHFEN
DHGVETTYEVNPINDYTPLMGLELSSDDIISIATNHLDFELIRRESGILC
GYGRYAGPESCAMPGYMCHYWILKSN
3D structure
PDB5x62 Substrate Recognition Mechanism of the Putative Yeast Carnosine N-methyltransferase
ChainA
Resolution2.204 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.22: carnosine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A R111 G146 E167 F168 M172 S234 F235 N274 F275 F276 T279 Y371 R104 G139 E160 F161 M165 S222 F223 N262 F263 F264 T267 Y352 PDBbind-CN: -logKd/Ki=6.42,Kd=379nM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0030735 carnosine N-methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0035498 carnosine metabolic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5x62, PDBe:5x62, PDBj:5x62
PDBsum5x62
PubMed28654751
UniProtP53934|CARME_YEAST Carnosine N-methyltransferase (Gene Name=YNL092W)

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