Structure of PDB 5x50 Chain A

Receptor sequence
>5x50A (length=1409) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence]
YSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREGGLND
PKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKKVCEC
ICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEADAPVD
EYSEQKSRGGCGNTQPVVRKDGMKLWGTWKDAQPERKLLTEILNVFKHIS
PEDCFRLGFNEDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDDLTHK
LSDILKANINVQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQPQAL
QKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLELDQVG
VPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRIDL
RYHKRAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVMPY
STFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQ
SNKPVMGIVQDTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVPQPAI
LKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGKVMFG
VVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNGFSIG
IGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRESFE
GEVSRTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSACV
GQQMVEGKRIAFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEFFF
HAMAGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLGDIIQ
FLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPDVIEY
AADILGDVELQKELNSEYEQLVSDRKFLREFVNGDHNWPLPVNLRRIIQN
AQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQNATS
LFQCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGEMVGV
IAAQSIGEPATQMTLNTFHVTLGVPRLKEILNVAKNIKTPALTVYLDREI
ALDIEKAKVIQSSIEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYF
SIQSPWLLRLELDRARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADK
LIIRCRVIAEEDQMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDES
GEYKNEELWALETDGINLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATR
SSLYKEILNVIAFDGSYVNYRHMALLVDVMTSRGYLMAITRHGINRADTG
ALMRCSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMI
DEKLLTSLP
3D structure
PDB5x50 Crystal structure of RNA polymerase II from Komagataella pastoris
ChainA
Resolution4.293 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C148 C168 C143 C161
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5x50, PDBe:5x50, PDBj:5x50
PDBsum5x50
PubMed28412353
UniProtC4R4Y0

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