Structure of PDB 5x4z Chain A

Receptor sequence
>5x4zA (length=1384) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence]
YSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREGGLND
PKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKKVCEC
ICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEARGGCG
NTQPVVRKDGMKLWGTWQPERKLLEILNVFKHISPEDCFRLGFNEDYARP
EWMIITVLPVPPPQVRPSIAMDETTQGQDDLTHKLSDILKANINVQKLEM
DGSPQHIINEVEQLLQFHVATYMDNDIAGQPQALQKSGRPVKAIRARLKG
KEGRLRGNLMGKRVFSARTVISGDPNLELDQVGVPISIAKTLSYPETVTQ
YNIHRLTEYVRNGPNEHPGAKYVIRDNGDRIDLRYHKRAGDIVLQYGWKV
ERHLMDDDPVLFNRQPSLHKMSMMAHRVKVMPYSTFRLNLSVTSPYNADF
DGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPVMGIVQDTLCGVR
KMTLRDTFIEYEQVMNMLFWVPSWDGVVPQPAILKPKPLWTGKQLLSIAI
PSGIHLQRTDGGNSLLSPKDNGMLIVDGKVMFGVVDKKTVGSGGGGLIHT
VMREKGPKICAELFGNIQKVVNYWLLHNGFSIGIGDAIADASTMKEITHA
ISSAKEQVQEIIYKAQHNELELKPGMTLRESFEGEVSRTLNDARDSAGRS
AEMNLKDLNNVKQMVSAGSKGSFINIAQMSACVGQQMVEGKRIAFGFADR
SLPHFTKDDFSPESKGFVENSYLRLTPQEFFFHAMAGREGLIDTAVKTAE
TGYIQRRLVKALEDIMVHYDGTTRNSLGDIIQFLYGEDGLDGTQVERQTI
DTIPGSDKAFHKRYYVDLMDEKNSIKPDVIEYAADILGDVELQKELNSEY
EQLVSDRKFLRVFVNGDHNWPLPVNLRRIIQNAQQIFHLDRAKASDLTIP
EIIHGVRDLCKKLFVLRGENELIKEAQQNATSLFQCLVRARLATRRILEE
FRLNRDAFEWVLGTIEAQFQRSLVHPGEMVGVIAAQSIGEPATQMTLNTF
HVTLGVPRLKEILNVAKNIKTPALTVYLDREIALDIEKAKVIQSSIYTTL
KNVTSATEIYYDPDPTSTVIEEDFDTVEAYFSIQSPWLLRLELDRARMLD
KQLTMNQVADKISEVFSDDLFVMWSEDNADKLIIRCRVIAEEDQMLKRIE
AHMLDLIALRIPGISKVYMVKHKVSVPDESGEYKNEELWALETDGINLAE
VMAVPGVDSSRTYSNSFVEILSVLGIEATRSSLYKEILNVIAFDGSYVNY
RHMALLVDVMTSRGYLMAITRHGINRADTALMRCSFEETVEILFEAGAAA
ELDDCRGVSENVMLGQLAPMGTGAFDVMIDEKLL
3D structure
PDB5x4z Crystal structure of RNA polymerase II from Komagataella pastoris
ChainA
Resolution7.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C107 C110 C148 C102 C105 C143
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5x4z, PDBe:5x4z, PDBj:5x4z
PDBsum5x4z
PubMed28412353
UniProtC4R4Y0

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